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Will Contrave Really Improve Weight Loss?
To what lengths would you go to lose weight? Would you try an unproven, potentially dangerous prescription drug – one that is made up of an antidepressant and an addiction medication?
If the answer is “yes,” then you might be interested in Contrave – an experimental drug being developed by Orexigen Therapeutics Inc. Is it dangerous? This drug has been tested since 2007, and has been wildly anticipated by patients and doctors alike, but we need to do a little more research before we can jump on the bandwagon.
What’s Different about Contrave?
With hundreds of diet pills on the market, not to mention the plethora of pills that doctors can prescribe for obesity, why does Contrave stand out? The biggest difference, according to experts, is that Contrave doesn’t work in the belly. It works in the hypothalamus, which is the brain’s central thermostat that controls appetite, temperature, and how the body burns energy.
From the beginning, one of the side-effects of the Wellbutrin treatment was weight loss. Wellbutrin is the antidepressant included in the two-part system of Contrave. The problem is that this effect soon wears off and people regain weight. That’s where the naltrexone comes in, says endocrinologist Dennis D. Kim, MD, MBA, Orexigen’s senior vice president for medical affairs.
According to Kim, “Naltrexone comes in and lifts the brake on the Wellbutrin effect so you have a synergistic effect to signal the hypothalamus to reduce food intake. Weight decrease is maintained over time.”
Does Contrave Work?
Contrave was tested in a clinical trial that enrolled nearly 700 obese people — 90% of them women with an average weight of 223 pounds. All participants enrolled in an intensive weight loss program that included counseling, diet, and exercise. Two-thirds of the study participants also took Contrave.
Less than 60% of the participants stayed in the program for 56 weeks but those who stayed reaped tremendous benefits. Those who took Contrave did significantly better than those who did not. After 56 weeks, they lost 9.3% of their body weight — 20 to 25 pounds. And 29% of them lost more than 15% of their body weight.
Is Contrave Safe?
You might be wondering if any of the participants who underwent Contrave treatment experienced any side effects. Most reported feeling mild to moderate nausea as well as headaches and constipation. All these side effects tended to occur early in the study.
What about the antidepressants and addiction drugs? Did those have an emotional effect on the participants? According to the reports, patients on Contrave did not suffer worsening depression or psychiatric symptoms. In fact, they reported better quality of life than other participants.
Conclusion
It is obvious that most intense weight loss supplements will only have improved results with the implementation of exercise, dieting, and counseling. Additional studies are still needed to determine how well Contrave works when combined with less drastic programs. Kim says that they “don’t expect an intensive diet and exercise program to be needed in order for Contrave to work well.”
In February 2011, the FDA rejected the drug and it was decided that an extremely large-scale study of the long-term cardiovascular effects of Contrave would be needed, before approval could be considered. We would recommend reading these studies when they are published before considering Contrave as a weight loss treatment.